Deep Brain Stimulation: An Emerging Technique in Treatment of Alzheimer’s disease
Abstract
Abstract
Deep brain stimulation is a therapeutic method that has been studied in animal experiments and clinical trials in degenerative diseases and has a huge potential if applied to Alzheimer's disease. In this review, it is described the deep brain stimulation technique and the underlying physical principles. It is also listed some of the most relevant studies performed in this scope to better understand the mechanisms of stimulation performance in relation to the improvement of cognitive performance related mainly to memory, neurogenesis and improved glucose metabolism and reduced expression of disease-causing proteins and increased levels of acetylcholine.
Keywords: deep brain stimulation; Alzheimer’s disease; neural stimulator; memory; neurogenesis; acetylcholine
Resumen
La estimulación cerebral profunda es un método terapéutico que se ha estudiado en experimentos con animales y ensayos clÃnicos en enfermedades degenerativas y tiene un enorme potencial si se aplica a la enfermedad de Alzheimer. En esta revisión, se describe la técnica de estimulación cerebral profunda y los principios fÃsicos subyacentes. También se enumeran algunos de los estudios más relevantes realizados en este ámbito para comprender mejor los mecanismos de la estimulación en relación con la mejora del rendimiento cognitivo relacionados principalmente con la memoria, la neurogenesis y el incremento del metabolismo de la glucosa y la reducción de la expresión de proteÃnas causantes de enfermedades bien como el aumento de niveles de acetilcolina.
Palabras clave: estimulación cerebral profunda; enfermedad de Alzheimer; estimulador neural; memoria; neurogenesis; acetilcolina
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Resumo
A estimulação cerebral profunda é um método terapêutico que foi estudado em estudos com animais e ensaios clÃnicos em doenças degenerativas e apresenta um enorme potencial se aplicado à doença de Alzheimer. Nesta revisão é descrita a técnica de estimulação cerebral profunda e os princÃpios fÃsicos subjacentes. São também enumerados alguns dos estudos mais relevantes realizados neste âmbito para melhor compreender os mecanismos de estimulação em relação à melhoria do desempenho cognitivo relacionado principalmente à memória, neurogénese e melhoria do metabolismo da glicose e redução da expressão de proteÃnas causadoras de doenças e aumento dos nÃveis de acetilcolina.
Palavras-chave: estimulação cerebral profunda; doença de Alzheimer; estimulador neural; memória; neurogénese; acetilcolina.
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