EFFECTS OF PREGNANCY AND LACTATION UNDERNUTRITION ON HIPPOCAMPUS MORPHOLOGY AND SPATIAL MEMORY IN 365-DAY-OLD RATS

Authors

  • Patricia Genovese Unidad Académica de Histología y Embriología, Departamentos de Biociencias, Facultad de Veterinaria, Universidad de la República, Uruguay.
  • Eva Genovese Unidad Académica de Histología y Embriología, Departamentos de Biociencias, Facultad de Veterinaria, Universidad de la República, Uruguay
  • Emiliano Herrera Unidad Académica de Histología y Embriología, Departamentos de Biociencias, Facultad de Veterinaria, Universidad de la República, Uruguay
  • Martín Duque Unidad Académica de Histología y Embriología, Departamentos de Biociencias, Facultad de Veterinaria, Universidad de la República, Uruguay
  • Alejandro Bielli Unidad Académica de Histología y Embriología, Departamentos de Biociencias, Facultad de Veterinaria, Universidad de la República, Uruguay
  • Paul Ruiz Unidad Académica de Fisiología, Departamentos de Biociencias, Facultad de Veterinaria, Universidad de la República, Uruguay

Abstract

Protein undernutrition during the perinatal period produces morphological alterations in the hippocampus and cognitive decline in adult rats. In the present study, we assessed the time spent and the number of errors made in a maze by 365-day-old male Wistar rats born to dams fed ad libitum or subjected to a 50% food restriction during pregnancy. At birth, all dams were fed ad libitum; however, the offspring of malnourished dams were assigned to larger litters in order to maintain the nutritional deprivation during lactation. Hematoxylin and Eosin staining was used to evaluate the thickness and length of different hippocampal regions. No significant treatment effects were observed in either behavioral or histological measures. However, in the CA1 region, a trend toward increased thickness was noted in treated rats.

Portada, Desierto Florido, Atacama, Chile. Fotografía Mariela Galindo

Published

08.12.2025 — Updated on 09.12.2025

How to Cite

Genovese , P., Genovese, E., Herrera , E., Duque, M., Bielli, A., & Ruiz, P. (2025). EFFECTS OF PREGNANCY AND LACTATION UNDERNUTRITION ON HIPPOCAMPUS MORPHOLOGY AND SPATIAL MEMORY IN 365-DAY-OLD RATS. Panamerican Journal of Neuropsychology, 19(2). Retrieved from https://www.cnps.cl/index.php/cnps/article/view/591

Issue

Vol. 19 No. 2 (2025): CNPs

Section

Original Papers

License

Copyright (c) 2025 Patricia Genovese , Eva Ganovese, Emiliano Herrera , Martín Duque, Alejandro Bielli, Paul Ruiz

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